It has been found that modifying the channel pattern of the FIR Compiler to certain values can lead to MATLAB/System Generator crashing.
For example, moving from Sequence ID List below:
to the following:
can cause a crash.
This is a known issue with System Generator 14.5 and MATLAB 2012b.
A patch exists for this issue for System Generator 14.5 and is attached to this answer record.