I have a Block Design (BD) containing HDL module blocks (Module reference).
When I change a module referenced in the BD, a yellow bar appears prompting me to "Refresh Changed Modules", so I click this link.
At this point, all of the existing Out-of-Context (OOC) design runs for the BDs disappear from the "Design Runs" tab.
When I tried to generate the BD output products again, it appears to start running, but no run is appearing in Design Runs.
Closing and reopening the project restores the runs view so that all of the BD design runs show up.
This issue is resolved in Vivado 2016.3.